Polyclonal Antibody Production Services
Polyclonal Antibody Production Services are vital tools for many applications and provide an excellent method to detect antigens in samples. They are used to capture or detect antigens in ELISAs and Western blotting, as well as to identify proteins in tissue sections for immunohistochemistry (IHC).

The key to the success of any antibody project is in the selection of the optimal antibody generation model, which depends on your needs and research objectives. Polyclonal antibodies offer several advantages over monoclonal antibodies (mAbs):

Unlike mAbs that are created from one single clone of B lymphocytes, polyclonal antibodies (pAbs) are secreted by multiple B lymphocyte clones. Because of this, they are capable of binding multiple epitopes, resulting in broader specificity. In addition, pAbs are less susceptible to degradation and lability, making them better suited for a variety of environments.

Tailored Antibody Services for Research and Diagnostics

The choice of animal host for antibody production is also an important factor to consider. Choosing a species that is phylogenetically distant from the target antigen will help to reduce the chance of cross-reactivity between the antibody and the epitopes you are interested in. Rabbits are commonly used to generate polyclonal antibodies because of their availability, genetic distance from human and mouse, and ability to produce high-titer and high-affinity antisera in small volumes with minimal adverse effects on the animal.

Outsourcing your antibody project to a reliable provider is crucial to ensure the highest quality results. Having a consistent workflow will not only minimize late-stage project failures but can also lower long-term development costs. This is why GeneArt HTP antibody expression services utilize fully traceable Matrix 2D barcoded sample tubes, exceptional quality standards, and a dedicated on-call team for consistent project communication.